Article
Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
International journal of laboratory hematology - 1 Oct 2021
Baba Shahid M, Shah Zafar A, Pandith Arshad A, Geelani Sajad A, Mir Mohammad M, Bhat Javid R, Gul Ayaz, Bhat Gul M
Abstract excerpt
INTRODUCTION: Glutathione S-transferase (GST) gene deletion or polymorphic sequence variations lead to decreased enzyme activity that influences susceptibility and response to tyrosine kinase inhibitors in chronic myeloid leukemia (CML). We aimed to analyze relation of different GST gene sequence variants with susceptibility and response to Imatinib in CML. MATERIAL AND METHODS: A total of 150 CML cases and equal...
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