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Influence of cytochrome P450 and glutathione S transferase polymorphisms on response to nilotinib therapy among chronic myeloidleukemia patients from Pakistan.

BMC cancer - 8 May 2022

Mukry Samina Naz, Shahni Aneeta, Zaidi Uzma, Sultan Shamsi Tahir

Abstract excerpt

BACKGROUND: Cytochrome P450 (CYP) and glutathione S transferases (GSTs) are important biotransforming enzymes responsible for detoxification of anticancer drugs and carcinogens. Polymorphisms in these enzymes may greatly influence the susceptibility to CML and overall efficacy of tyrosine kinase inhibitors. This study was aimed to estimate the possible influence of the polymorphisms of GSTs and CYP in the...

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Identifiers

PMID: 35527244
DOI: 10.1186/s12885-022-09605-1
PMCID: PMC9080200

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