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Influence of genetic polymorphisms in glutathione-S-transferases gene in response to imatinib among Brazilian patients with chronic myeloid leukemia.

Molecular biology reports - 1 Mar 2021

Delmond Kezia Aguiar, Delleon Hugo, Goveia Rebeca Mota, Teixeira Thallita Monteiro, Abreu Davi Carvalho, Mello-Andrade Francyelli, Reis Angela Adamski da Silva, Silva Daniela de Melo E, Barbosa Adriana do Prado, Tavares Renato Sampaio, Anunciação Carlos Eduardo, Silveira-Lacerda Elisângela

Abstract excerpt

Polymorphism in metabolizing enzymes can influence drug response as well as the risk for adverse drug reactions. Nevertheless, there are still few studies analyzing the consequence of polymorphisms for the Glutathione-S-transferases (GST) gene to drug response in chronic myeloid leukemia (CML). This study reports, the influence of GSTP1*B and GSTT1/GSTM1null polymorphisms in response to imatinib in CML patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33709282
DOI: 10.1007/s11033-020-06093-z

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