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A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer

4 Feb 2020

Abstract excerpt

The difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with both tumorigenesis and drug resistance. Unc-51-like kinase 1 (ULK1) is a serine/threonine kinase that participates in the initiation of autophagy. Many studies have indicated...

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PMID: 32033142
DOI: 10.3390/cancers12020352

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