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Article

Mutations in ZP4 are associated with abnormal zona pellucida and female infertility.

Journal of clinical pathology - 1 Mar 2022

Wei Xiaoli, Li Youzhu, Liu Qicai, Liu Wensheng, Yan Xiaohong, Zhu Xingshen, Zhou Dekun, Tian Yingpu, Zhang Fuxing, Li Na, Lu Zhongxian

Abstract excerpt

BACKGROUND: The zona pellucida (ZP) of human oocytes plays essential protective roles in sperm-egg interactions during fertilisation and embryo development. ZP4-null female rabbits exhibit a thin and irregular ZP, which severely impairs embryo development and fertility. However, the effects of ZP4 defect on human female reproduction remain unknown. METHODS AND RESULTS: We performed whole-exome sequencing in 26...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33461974
DOI: 10.1136/jclinpath-2020-207170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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