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Article

A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility.

American journal of human genetics - 7 Sept 2017

Chen Tailai, Bian Yuehong, Liu Xiaoman, Zhao Shigang, Wu Keliang, Yan Lei, Li Mei, Yang Zhenglin, Liu Hongbin, Zhao Han, Chen Zi-Jiang

Abstract excerpt

Empty follicle syndrome (EFS) is defined as the failure to aspirate oocytes from mature ovarian follicles during in vitro fertilization. Except for some cases caused by pharmacological or iatrogenic problems, the etiology of EFS remains enigmatic. In the present study, we describe a large family with a dominant inheritance pattern of female infertility characterized by recurrent EFS. Genome-wide linkage analyses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28886344
DOI: 10.1016/j.ajhg.2017.08.001
PMCID: PMC5590947

Genes

EFS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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