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Article

Association between COMT methylation and response to treatment in children with ADHD.

Journal of psychiatric research - 1 Mar 2021

Fageera Weam, Chaumette Boris, Fortier Marie-Ève, Grizenko Natalie, Labbe Aurelie, Sengupta Sarojini M, Joober Ridha

Abstract excerpt

BACKGROUND: COMT had been considered a promising candidate gene in pharmacogenetic studies in ADHD; yet the findings from these studies have been inconsistent. Part of these inconsistencies could be related to epigenetic mechanisms (including DNA methylation). Here we investigated the role of genetic variants of the COMT gene on the methylation levels of CpG sites in the same gene and explored the effect of...

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Share to Attention Deficit Disorder with Hyperactivity
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Central Nervous System Stimulants

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Source

Identifiers

PMID: 33453563
DOI: 10.1016/j.jpsychires.2021.01.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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