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Article

CD40 signaling in CD8+CD40+ T cells turns on contra-T regulatory cell functions.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2010

Martin Sunil, Pahari Sushmita, Sudan Raki, Saha Bhaskar

Abstract excerpt

CD4(+) regulatory T cells (Treg cells) mediate immunosuppression, whereas CD8(+) T cells confer resistance in many diseases. It is unknown whether CD8(+) T cells confer protection by antagonizing the Treg cells. Using a model of stage-specific immune responses against Leishmania donovani infection in susceptible BALB/c mice, we report that CD3(+)CD8(+)CD40(+) T cells executed CD40-dependent cytotoxicity on...

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Identifiers

PMID: 20400702
DOI: 10.4049/jimmunol.0902762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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