Article
Severe asthma is characterized by a sex-specific ILC landscape and aberrant airway profile that is suppressed by anti-IL-5/5Rα biologics.
Science translational medicine - 1 Oct 2025
Mincham Kyle T, Loewenthal Lola E, Meyer Garance F M, Fontanella Sara, Marfia Martina, Martin Minerva Garcia, Kaygusuz Viola, Goss Charlotte, Walker Simone A, Puttur Franz, Menzies-Gow Andrew, Patel Pujan, Lloyd Clare M, Snelgrove Robert J
Abstract excerpt
Innate lymphoid cells (ILCs) fulfill critical roles in maintenance of tissue-specific homeostasis but have also been implicated in disease pathology when dysregulated. Although they are broadly classified into three core subsets, it is increasingly apparent that ILCs exhibit plasticity in response to microenvironmental factors. Accurate and holistic evaluation of the ILC landscape is critical to understanding the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.