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Article

Genetic variants in arachidonic acid pathway genes associated with NSAID-exacerbated respiratory disease.

Pharmacogenomics - 1 Jul 2015

Ayuso Pedro, Plaza-Serón María Del Carmen, Blanca-López Natalia, Doña Inmaculada, Campo Paloma, Canto Gabriela, Laguna José Julio, Bartra Joan, Soriano-Gomis Victor, Blanca Miguel, Cornejo-García José A, Perkins James R

Abstract excerpt

AIM: NSAIDs are the most frequent cause of hypersensitivity drug reactions. We have examined the association between NSAID-exacerbated respiratory disease (NERD) and genetic variants in arachidonic acid metabolism genes. PATIENTS & METHODS: We included 250 NERD patients, 260 NSAID-tolerant asthmatic (NTA) subjects and 315 healthy controls. RESULTS: Significant associations with NERD were identified for: ALOX15...

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Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Arachidonate 15-Lipoxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arachidonic Acid

Share to Cyclooxygenase 1

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Source

Identifiers

PMID: 26067486
DOI: 10.2217/pgs.15.43

Genes

ALOX15
ALOX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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