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Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage.

Nature communications - 21 Sept 2017

Chen Poyu, Takatsuka Hirotomo, Takahashi Naoki, Kurata Rie, Fukao Yoichiro, Kobayashi Kosuke, Ito Masaki, Umeda Masaaki

Abstract excerpt

Inhibition of cell division is an active response to DNA damage that enables cells to maintain genome integrity. However, how DNA damage arrests the plant cell cycle is largely unknown. Here, we show that the repressor-type R1R2R3-Myb transcription factors (Rep-MYBs), which suppress G2/M-specific genes, are required to inhibit cell division in response to DNA damage. Knockout mutants are resistant to agents that...

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Identifiers

PMID: 28935922
DOI: 10.1038/s41467-017-00676-4
PMCID: PMC5608833

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MYB

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