Article
A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking.
eLife - 27 Apr 2020
Susa Katherine J, Seegar Tom Cm, Blacklow Stephen C, Kruse Andrew C
Abstract excerpt
CD81 and its binding partner CD19 are core subunits of the B cell co-receptor complex. While CD19 belongs to the extensively studied Ig superfamily, CD81 belongs to a poorly understood family of four-pass transmembrane proteins called tetraspanins. Tetraspanins play important physiological roles by controlling protein trafficking and other processes. Here, we show that CD81 relies on its ectodomain to traffic...
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