Article

Recent advances in understanding hematopoiesis in Fanconi Anemia

2018-01-24

Abstract excerpt

Fanconi anemia is an inherited disease characterized by genomic instability, hypersensitivity to DNA cross-linking agents, bone marrow failure, short stature, skeletal abnormalities, and a high relative risk of myeloid leukemia and epithelial malignancies. The 21 Fanconi anemia genes encode proteins involved in multiple nuclear biochemical pathways that effect DNA interstrand crosslink repair. In the past, bone ma...

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Literature Corpus work: 3335f7b3-313b-549b-9318-bdaf6969308b
DOI: 10.12688/f1000research.13213.1

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