Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[PI3K isoforms PI3Kβ and PI3Kδ play different roles in KIT mutation-mediated cell transformation].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology - 1 Jan 2021

Zhang Shaoting, Zhu Guangrong, Shi Jun, Yang Jihui, Jiang Zongying, Zhang Liangying, Dou Kaikai, Sun Jianmin

Abstract excerpt

Objective To investigate the role of phosphatidylinositol 3-kinase (PI3K) isoforms in type III receptor tyrosine kinase KIT mutation-mediated signaling and cell proliferation. Methods The wild-type KIT and the common KIT mutations V560D and W557K558del in gastrointestinal stromal tumors (GIST) were stably expressed in BaF3 cells. The cells were treated with PI3K isoforms PI3Kα, PI3Kβ and PI3Kδ specific inhibitors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Phosphatidylinositol 3-Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Protein Isoforms

Source

Identifiers

PMID: 33441227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[PI3K isoforms PI3Kβ and PI3Kδ play different roles in KIT mutation-mediated cell transformation].PMID 33441227Read ↗

KIT over-expression by p55PIK-PI3K leads to Imatinib-resistance in patients with gastrointestinal stromal tumors.Semantic proximity Read ↗

Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.Semantic proximity Read ↗

[Oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor].Semantic proximity Read ↗

Gab2 Is Involved in Differential Phosphoinositide 3-Kinase Signaling by Two Splice Forms of c-KitSemantic proximity Read ↗

BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor.Semantic proximity Read ↗

Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors.Semantic proximity Read ↗

[Transforming effect of PDGFRA gene mutant on the cell function in gastrointestinal stromal tumor].Semantic proximity Read ↗

KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors.Semantic proximity Read ↗

p110δ PI3 kinase pathway: emerging roles in cancerSemantic proximity Read ↗

RAF1 facilitates KIT signaling and serves as a potential treatment target for gastrointestinal stromal tumor.Semantic proximity Read ↗

Oncogenic signaling of class I PI3K isoforms.Semantic proximity Read ↗

Stem cell factor-mediated wild-type KIT receptor activation is critical for gastrointestinal stromal tumor cell growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.