Article
The interaction of early life factors and depression-associated loci affecting the age at onset of the depression.
Translational psychiatry - 25 Jul 2022
Chen Yujing, Pan Chuyu, Cheng Shiqiang, Li Chun'e, Zhang Huijie, Zhang Zhen, Zhang Jingxi, Yao Yao, Meng Peilin, Yang Xuena, Liu Li, Cheng Bolun, Jia Yumeng, Wen Yan, Zhang Feng
Abstract excerpt
Multiple previous studies explored the associations between early life factors and the age at onset of the depression. However, they only focused on the influence of environmental or genetic factors, without considering the interactions between them. Based on previous genome-wide association study (GWAS) data, we first calculated polygenic risk score (PRS) for depression. Regression analyses were conducted to...
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