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Article

Structure-Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors.

International journal of molecular sciences - 10 Jan 2021

Elsocht Mathias, Giron Philippe, Maes Laila, Versées Wim, Gutierrez Gustavo J, De Grève Jacques, Ballet Steven

Abstract excerpt

Lung cancer is one of the most frequently diagnosed cancers accounting for the highest number of cancer-related deaths in the world. Despite significant progress including targeted therapies and immunotherapy, the treatment of advanced lung cancer remains challenging. Targeted therapies are highly efficacious at prolonging life, but not curative. In prior work we have identified Ubiquitin Specific Protease 13...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33435251
DOI: 10.3390/ijms22020635
PMCID: PMC7827406

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