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The mystery of titan hunter: Rationalized striking of the MAPK pathway via Newly synthesized 6-Indolylpyridone-3-Carbonitrile derivatives.

European journal of medicinal chemistry - 5 Nov 2023

Saleh Mohamed M, El-Moselhy Tarek, El-Bastawissy Eman, Ibrahim Mahmoud A A, Sayed Shaban R M, Hegazy Mohamed-Elamir F, Efferth Thomas, Jaragh-Alhadad Laila A, Sidhom Peter A

Abstract excerpt

MAPK pathway sparkles with RTK activation, passes through subsequent downstream RAS-RAF-MEK-ERK signaling cascades, with consequent direct and indirect CDK4/6 signaling activation, and ends with cell survival, division, and proliferation. However, the emergence of anomalies such as mutations or overexpression in one or more points of the pathway could lead to cancer development and drug resistance. Therefore,...

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PMID: 37506545
DOI: 10.1016/j.ejmech.2023.115675

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