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Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218)

24 Jan 2014

Abstract excerpt

The invention described in this review (WO2013030218) relates to compounds based on the quinazolin-4-one scaffold, their process of preparation and applications to inhibit the ubiquitin-specific protease 7 (USP7), a deubiquitinating enzyme (DUB), which is considered a potentially important new drug target for treating cancer and immunological disorders. Data are presented indicating that these small-molecule...

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PMID: 24456106
DOI: 10.1517/13543776.2014.882320

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