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Article

Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor.

Journal of medicinal chemistry - 8 Apr 2010

Pawar Vijaykumar G, Sos Martin L, Rode Haridas B, Rabiller Matthias, Heynck Stefanie, van Otterlo Willem A L, Thomas Roman K, Rauh Daniel

Abstract excerpt

The mutant receptor tyrosine kinase EGFR is a validated and therapeutically amenable target for genotypically selected lung cancer patients. Here we present the synthesis and biological evaluation of a series of 6- and 7-substituted 4-anilinoquinolines as potent type I inhibitors of clinically relevant mutant variants of EGFR. Quinolines 3a and 3e were found to be highly active kinase inhibitors in biochemical...

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Identifiers

PMID: 20222733
DOI: 10.1021/jm901877j

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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