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Article

PPARγ is dispensable for clear cell renal cell carcinoma progression

21 May 2018

Abstract excerpt

OBJECTIVE: Clear cell renal cell carcinoma (ccRCC) is a subtype of kidney cancer defined by robust lipid accumulation, which prior studies have indicated plays an important role in tumor progression. We hypothesized that the peroxisome proliferator-activated receptor gamma (PPARγ), detected in both ccRCC tumors and cell lines, promotes lipid storage in ccRCC and contributes to tumorigenesis in this setting. PPARγ...

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Share to Cancer, Lipids, and Metabolism
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Identifiers

PMID: 29866440
DOI: 10.1016/j.molmet.2018.05.013

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