Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>Centella asiatica</i>Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action

1 Jan 2012

Abstract excerpt

Centella asiatica (CA), commonly named gotu kola, is an Ayurvedic herb used to enhance memory and nerve function. To investigate the potential use of CA in Alzheimer's disease (AD), we examined the effects of a water extract of CA (GKW) in the Tg2576 mouse, a murine model of AD with high β-amyloid burden. Orally administered GKW attenuated β-amyloid-associated behavioral abnormalities in these mice. In vitro, GKW...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholinesterase and Neurodegenerative Diseases
Share to Medicinal Plants and Neuroprotection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22506133
DOI: 10.1155/2012/381974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>Centella asiatica</i>Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of ActionPMID 22506133Read ↗

Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageingSemantic proximity Read ↗

Caralluma dalzielii as a Potential Therapy for Alzheimer’s Disease: Insights from a Transgenic Drosophila melanogaster ModelSemantic proximity Read ↗

A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.Semantic proximity Read ↗

Centella asiatica promotes antioxidant gene expression and mitochondrial oxidative respiration in experimental autoimmune encephalomyelitisSemantic proximity Read ↗

Gracilins: Spongionella-derived promising compounds for Alzheimer disease.Semantic proximity Read ↗

A novel drug candidate for Alzheimer's disease treatment: gx-50 derived from Zanthoxylum bungeanum.Semantic proximity Read ↗

Cajanus cajan (L) Millsp. seed extract ameliorated scopolamine-induced amnesia through increase in antioxidant defense mechanisms and cholinergic neurotransmissionSemantic proximity Read ↗

Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer's DiseaseSemantic proximity Read ↗

Protective effect of Allium jesdianum in an Alzheimer's disease induced rat modelSemantic proximity Read ↗

Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in 5XFAD miceSemantic proximity Read ↗

Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune EncephalomyelitisSemantic proximity Read ↗

Obovatol improves cognitive functions in animal models for Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.