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Article

Evidence of B Cell Clonality and Investigation Into Properties of the IgM in Patients With Schnitzler Syndrome.

Frontiers in immunology - 1 Jan 2020

Pathak Shelly, Rowczenio Dorota, Lara-Reyna Samuel, Kacar Mark, Owen Roger, Doody Gina, Krause Karoline, Lachmann Helen, Doffinger Rainer, Newton Darren, Savic Sinisa

Abstract excerpt

The Schnitzler Syndrome (SchS) is an acquired, autoinflammatory condition successfully treated with IL-1 inhibition. The two main defining features of this late-onset condition are neutrophilic urticarial dermatoses (NUD) and the presence of an IgM monoclonal component. While the former aspect has been extensively studied in this disease setting, the enigmatic paraproteinaemia and its potential consequential...

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Identifiers

PMID: 33424831
DOI: 10.3389/fimmu.2020.569006
PMCID: PMC7793813

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