Article
Paraproteinemias in Sjögren disease: cryoglobulinemia and serum monoclonal gammopathy identify distinct clinical phenotypes and differential lymphoma susceptibility.
Seminars in arthritis and rheumatism - 1 Jun 2026
Longhino Simone, Rizzo Maria Teresa, Manfrè Valeria, Cafaro Giacomo, De Martino Maria, Carubbi Francesco, Alunno Alessia, Del Papa Nicoletta, Cipriani Paola, Atzeni Fabiola, Berardicurti Onorina, Giacomelli Roberto, Colafrancesco Serena, Priori Roberta, Manisera Ludovica, Gattamelata Angelica, Guiducci Serena, Baldini Chiara, Bartoloni Elena, Quartuccio Luca
Abstract excerpt
OBJECTIVE: Sjögren disease (SjD) is a systemic autoimmune disease characterized by increased risk of B-cell non-Hodgkin lymphoma. Although cryoglobulinemia and serum monoclonal component (MC) are well-recognized paraproteinemias in SjD, no large-scale study has directly compared their isolated and combined impact on phenotype and lymphoproliferative risk. METHODS: A retrospective, multicenter, cross-sectional...
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