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Article

Insulin-like growth factor 2 (IGF2) expression in adrenocortical disease due to PRKAR1A mutations compared to other benign adrenal tumors.

Endocrine - 1 Jun 2021

Nadella Kiran S, Berthon Annabel, Almeida Madson Q, Levy Isaac, Faucz Fabio R, Stratakis Constantine A

Abstract excerpt

PURPOSE: Insulin-like growth factor-II (IGF2), a key regulator of cell growth and development, is tightly regulated in its expression by epigenetic control that maintains its monoallelic expression in most tissues. Biallelic expression of IGF2 resulting from loss of imprinting (LOI) has been reported in adrenocortical tumors. In this study, we wanted to check whether adrenocortical lesions due to PRKAR1A...

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PMID: 33420948
DOI: 10.1007/s12020-020-02583-z

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