Article
Hypoxia-reoxygenation induces macrophage polarization and causes the release of exosomal miR-29a to mediate cardiomyocyte pyroptosis.
In vitro cellular & developmental biology. Animal - 1 Jan 2021
Wang Yan, Qiu Zhimei, Yuan Jinson, Li Chaofu, Zhao Ranzun, Liu Weiwei, Deng Wenwen, Gu Ning, Zhang Wei, Hu Shan, Bai Zhixun, Shi Bei
Abstract excerpt
To investigate the mechanism by which hypoxia-reoxygenation (HR) mediates macrophage polarization to the M1 phenotype and then mediates cardiomyocyte (CM) pyroptosis through exosome release. Mouse bone marrow macrophages and CMs were cultured in vitro under hypoxia for 12 h and reoxygenation for 6 h to establish an HR cell model. qPCR was used to detect the M1 or M2 macrophage markers IL-1β, TNF-α, MR, and Arg,...
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