Article
Molecular alterations during progression of prostate cancer to androgen independence.
Clinical chemistry - 1 Oct 2011
Saraon Punit, Jarvi Keith, Diamandis Eleftherios P
Abstract excerpt
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer among men in North America and is a leading cause of death. Standard treatments include androgen deprivation therapy, which leads to improved clinical outcomes. However, over time, most tumors become androgen independent and no longer respond to hormonal therapies. Several mechanisms have been implicated in the progression of prostate cancer to...
Topics
- Androgen Antagonists
- Disease Progression
- Drug Resistance, Neoplasm
- Epigenesis, Genetic
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Humans
- Male
- MicroRNAs
- Mutation
- Prostatic Neoplasms