Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells

1 May 2012

Abstract excerpt

PURPOSE: The use of aromatase inhibitors (AI) in the treatment of estrogen receptor (ER)-positive, postmenopausal breast cancer has proven efficacy. However, inappropriate activation of ER target genes has been implicated in the development of resistant tumors. The ER coactivator protein AIB1 has previously been associated with initiation of breast cancer and resistance to endocrine therapy. EXPERIMENTAL DESIGN:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to HER2/EGFR in Cancer Research
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22550166
DOI: 10.1158/1078-0432.ccr-11-3300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer CellsPMID 22550166Read ↗

Amplified in Breast Cancer 1 in Human Epidermal Growth Factor Receptor–Positive Tumors of Tamoxifen-Treated Breast Cancer PatientsSemantic proximity Read ↗

Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype.Semantic proximity Read ↗

The nuclear receptor coactivator AIB1 mediates insulin-like growth factor I-induced phenotypic changes in human breast cancer cells.Semantic proximity Read ↗

Phenotypic alterations in breast cancer cells overexpressing the nuclear receptor co-activator AIB1.Semantic proximity Read ↗

An “Omics” Approach to Determine the Mechanisms of Acquired Aromatase Inhibitor ResistanceSemantic proximity Read ↗

Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancerSemantic proximity Read ↗

STAT 1 facilitates oestrogen receptor α transcription and stimulates breast cancer cell proliferationSemantic proximity Read ↗

Molecular profiling of aromatase inhibitor sensitive and resistant ER+HER2- postmenopausal breast cancersSemantic proximity Read ↗

Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) Drives Proliferation of IPH-926 lobular Carcinoma CellsSemantic proximity Read ↗

Identification of a novel estrogen receptor β1 binding partner, inhibitor of differentiation-1, and role of ERβ1 in human breast cancer cellsSemantic proximity Read ↗

Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancerSemantic proximity Read ↗

BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.