Article
Genome-Wide Association of Kidney Traits in Hispanics/Latinos Using Dense Imputed Whole-Genome Sequencing Data: The Hispanic Community Health Study/Study of Latinos.
Circulation. Genomic and precision medicine - 1 Aug 2020
Qian Huijun, Kowalski Madeline H, Kramer Holly J, Tao Ran, Lash James P, Stilp Adrienne M, Cai Jianwen, Li Yun, Franceschini Nora
Abstract excerpt
BACKGROUND: Genetic factors that influence kidney traits have been understudied for low-frequency and ancestry-specific variants. METHODS: This study used imputed whole-genome sequencing from the Trans-Omics for Precision Medicine project to identify novel loci for estimated glomerular filtration rate and urine albumin-to-creatinine ratio in up to 12 207 Hispanics/Latinos. Replication was performed in the Women's...
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