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Article

Systems genetics identifies a co-regulated module of liver microRNAs associated with plasma LDL cholesterol in murine diet-induced dyslipidemia.

Physiological genomics - 1 Nov 2017

Coffey Alisha R, Smallwood Tangi L, Albright Jody, Hua Kunjie, Kanke Matt, Pomp Daniel, Bennett Brian J, Sethupathy Praveen

Abstract excerpt

Chronically altered levels of circulating lipids, termed dyslipidemia, is a significant risk factor for a number of metabolic and cardiovascular morbidities. MicroRNAs (miRNAs) have emerged as important regulators of lipid balance, have been implicated in dyslipidemia, and have been proposed as candidate therapeutic targets in lipid-related disorders including atherosclerosis. A major limitation of most murine...

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Cholesterol, LDL
Diet, High-Fat
Dyslipidemias
Gene Regulatory Networks
Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28916633
DOI: 10.1152/physiolgenomics.00050.2017
PMCID: PMC5792136

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