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Examining the genetic relationship between Alzheimer’s disease, schizophrenia and their shared risk factors using genomic structural equation modelling

1 Jan 2025

Abstract excerpt

Epidemiological studies have demonstrated an association between dementia and schizophrenia. There is a significant symptom overlap between the two disorders-psychosis is seen in 50% of patients with Alzheimer's disease and cognitive impairment is a key feature of schizophrenia. Whether these overlapping clinical presentations reflect shared aetiology is unclear. Therefore, we aimed to model the genetic...

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PMID: 40212341
DOI: 10.1093/braincomms/fcaf112

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