Article
ARG2 single-nucleotide polymorphism rs3742879 affects plasma arginase 2 levels, nitric oxide formation and antihypertensive therapy response in preeclampsia.
Pharmacogenomics - 1 Aug 2022
Luizon Marcelo R, Pinto-Souza Caroline C, Coeli-Lacchini Fernanda, Lacchini Riccardo, Cavalli Ricardo C, Sandrim Valeria C
Abstract excerpt
Aim: This work examined whether ARG1 (rs2781659, rs2781667, rs2246012 and rs17599586) and ARG2 (rs3742879 and rs10483801) single-nucleotide polymorphisms (SNPs) are associated with antihypertensive therapy responsiveness in preeclampsia (PE) and their effects on arginase isoforms and nitrite concentrations in responsive and nonresponsive patients. Methods: SNP genotypes were determined by TaqMan assays. Plasma...