Article
Association of novel rare coding variants with juvenile idiopathic arthritis.
Annals of the rheumatic diseases - 1 May 2021
Meng Xinyi, Hou Xiaoyuan, Wang Ping, Glessner Joseph T, Qu Hui-Qi, March Michael E, Zhang Sipeng, Qi Xiaohui, Zhu Chonggui, Nguyen Kenny, Gao Xinyi, Li Xiaoge, Liu Yichuan, Zhou Wentao, Zhang Shuyue, Li Junyi, Sun Yan, Yang Jie, Sleiman Patrick M A, Xia Qianghua, Hakonarson Hakon, Li Jin
Abstract excerpt
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is the most common type of arthritis among children, but a few studies have investigated the contribution of rare variants to JIA. In this study, we aimed to identify rare coding variants associated with JIA for the genome-wide landscape. METHODS: We established a rare variant calling and filtering pipeline and performed rare coding variant and gene-based association...
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