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Article

The UVSSA complex alleviates MYC-driven transcription stress.

The Journal of cell biology - 1 Feb 2021

Sato Mai, Liebau Rowyn C., Liu Zhaoqi, Liu Lizhi, Rabadan Raul, Gautier Jean

Abstract excerpt

Cancer cells develop strong genetic dependencies, enabling survival under oncogenic stress. MYC is a key oncogene activated across most cancers, and identifying associated synthetic lethality or sickness can provide important clues about its activity and potential therapeutic strategies. On the basis of previously conducted genome-wide screenings in MCF10A cells expressing MYC fused to an estrogen receptor...

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Identifiers

PMID: 33404608
DOI: 10.1083/jcb.201807163
PMCID: PMC7791342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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