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Article

A Developed NK-92MI Cell Line with Siglec-7neg Phenotype Exhibits High and Sustainable Cytotoxicity against Leukemia Cells.

International journal of molecular sciences - 4 Apr 2018

Huang Chin-Han, Liao Yi-Jen, Fan Ting-Hsi, Chiou Tzeon-Jye, Lin Yen-Hsi, Twu Yuh-Ching

Abstract excerpt

Altered sialic acid processing that leads to upregulation of cell surface sialylation is recognized as a key change in malignant tissue glycosylation. This cancer-associated hypersialylation directly impacts the signaling interactions between tumor cells and their surrounding microenvironment, especially the interactions mediated by immune cell surface sialic acid-binding immunoglobulin-like lectins (Siglecs) to...

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Share to Cell Degranulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29617289
DOI: 10.3390/ijms19041073
PMCID: PMC5979288

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