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Article

Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency.

Molecular brain - 5 Jan 2021

Choi Dong Il, Kim Myeongwon, Kim Somi, Yu Nam-Kyung, Kwak Chuljung, Seo Hyunhyo, Lee Kyungmin, Kaang Bong-Kiun

Abstract excerpt

CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive gliosis of astrocytes and microglia followed by age-dependent cell death in the excitatory neurons of CTCF cKO mice. To assess the cognitive ability in CTCF cKO mice...

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Identifiers

PMID: 33402211
DOI: 10.1186/s13041-020-00716-z
PMCID: PMC7784033

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