Article
Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation.
Nature genetics - 1 Jul 2002
Park Chankyu, Falls William, Finger Jacqueline H, Longo-Guess Chantal M, Ackerman Susan L
Abstract excerpt
Mice homozygous for the cerebellar deficient folia (cdf) mutation are ataxic and have cerebellar hypoplasia and abnormal lobulation of the cerebellum. In the cerebella of cdf/cdf homozygous mice, approximately 40% of Purkinje cells are located ectopically in the white matter and inner granule-cell layer. Many hippocampal pyramidal cells are scattered in the plexiform layers, and those that are correctly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.