Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pan-Cancer Molecular Patterns and Biological Implications Associated with a Tumor-Specific Molecular Signature.

Cells - 31 Dec 2020

Rocha Darío, García Iris A, González Montoro Aldana, Llera Andrea, Prato Laura, Girotti María R, Soria Gastón, Fernández Elmer A

Abstract excerpt

Studying tissue-independent components of cancer and defining pan-cancer subtypes could be addressed using tissue-specific molecular signatures if classification errors are controlled. Since PAM50 is a well-known, United States Food and Drug Administration (FDA)-approved and commercially available breast cancer signature, we applied it with uncertainty assessment to classify tumor samples from over 33 cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Centrosome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Inhibitory Concentration 50

Share to Proportional Hazards Models

Share to Receptor, ErbB-2

Share to Retinoblastoma Binding Proteins

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 33396205
DOI: 10.3390/cells10010045
PMCID: PMC7823585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pan-Cancer Molecular Patterns and Biological Implications Associated with a Tumor-Specific Molecular Signature.PMID 33396205Read ↗

Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases.Semantic proximity Read ↗

Association of BRCA1- and BRCA2-deficiency with mutation burden, expression of PD-L1/PD-1, immune infiltrates, and T cell-inflamed signature in breast cancerSemantic proximity Read ↗

Robust and Interpretable PAM50 Reclassification Exhibits Survival Advantage for Myoepithelial and Immune PhenotypesSemantic proximity Read ↗

Impact of Clonal Hematopoiesis of Indeterminate Potential on Treatment Response and Tumor Microenvironment in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.Semantic proximity Read ↗

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification.Semantic proximity Read ↗

Gene Co-Expression Modules as Clinically Relevant Hallmarks of Breast Cancer DiversitySemantic proximity Read ↗

Cross-Platform Reproducible Modeling of Breast Cancer Prognosis Using the Core-PAM50 Gene SignatureSemantic proximity Read ↗

A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy.Semantic proximity Read ↗

A unifying functional dichotomy organises breast cancer molecular landscape, resolves PIK3CA ambiguity, and supports tiered tumour classificationSemantic proximity Read ↗

Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue.Semantic proximity Read ↗

DEPTH2 score was associated with cell proliferation and immune cell infiltrations but not with systemic treatment response in breast cancerSemantic proximity Read ↗

PAM50 assay and the three-gene model for identifying the major and clinically relevant molecular subtypes of breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.