Article
Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification.
Cold Spring Harbor molecular case studies - 1 Nov 2016
Gröschel Stefan, Bommer Martin, Hutter Barbara, Budczies Jan, Bonekamp David, Heining Christoph, Horak Peter, Fröhlich Martina, Uhrig Sebastian, Hübschmann Daniel, Geörg Christina, Richter Daniela, Pfarr Nicole, Pfütze Katrin, Wolf Stephan, Schirmacher Peter, Jäger Dirk, von Kalle Christof, Brors Benedikt, Glimm Hanno, Weichert Wilko, Stenzinger Albrecht, Fröhling Stefan
Abstract excerpt
Identification of the tissue of origin in cancer of unknown primary (CUP) poses a diagnostic challenge and is critical for directing site-specific therapy. Currently, clinical decision-making in patients with CUP primarily relies on histopathology and clinical features. Comprehensive molecular profiling has the potential to contribute to diagnostic categorization and, most importantly, guide CUP therapy through...
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