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Article

Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue.

Breast cancer research and treatment - 1 Jan 2010

Chen Dung-Tsa, Nasir Aejaz, Culhane Aedin, Venkataramu Chinnambally, Fulp William, Rubio Renee, Wang Tao, Agrawal Deepak, McCarthy Susan M, Gruidl Mike, Bloom Gregory, Anderson Tove, White Joe, Quackenbush John, Yeatman Timothy

Abstract excerpt

Historical data have indicated the potential for the histologically-normal breast to harbor pre-malignant changes at the molecular level. We postulated that a histologically-normal tissue with "tumor-like" gene expression pattern might harbor substantial risk for future cancer development. Genes associated with these high-risk tissues were considered to be "malignancy-risk genes". From a total of 90 breast cancer...

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Identifiers

PMID: 19266279
DOI: 10.1007/s10549-009-0344-y
PMCID: PMC2796276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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