Article
Giant Magnetoresistive Nanosensor Analysis of Circulating Tumor DNA Epidermal Growth Factor Receptor Mutations for Diagnosis and Therapy Response Monitoring.
Clinical chemistry - 1 Mar 2021
Nesvet Jared C, Antilla Katie A, Pancirer Danielle S, Lozano Alexander X, Preiss Jordan S, Ma Weijie, Fu Aihua, Park Seung-Min, Gambhir Sanjiv S, Fan Alice C, Neal Joel W, Padda Sukhmani K, Das Millie, Li Tianhong, Wakelee Heather A, Wang Shan X
Abstract excerpt
BACKGROUND: Liquid biopsy circulating tumor DNA (ctDNA) mutational analysis holds great promises for precision medicine targeted therapy and more effective cancer management. However, its wide adoption is hampered by high cost and long turnaround time of sequencing assays, or by inadequate analytical sensitivity of existing portable nucleic acid tests to mutant allelic fraction in ctDNA. METHODS: We developed a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.