A Highly Sensitive and Quantitative Test Platform for Detection of NSCLC EGFR Mutations in Urine and Plasma.

doi:10.1016/j.jtho.2016.05.035

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Article

A Highly Sensitive and Quantitative Test Platform for Detection of NSCLC EGFR Mutations in Urine and Plasma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2016

Reckamp Karen L, Melnikova Vladislava O, Karlovich Chris, Sequist Lecia V, Camidge D Ross, Wakelee Heather, Perol Maurice, Oxnard Geoffrey R, Kosco Karena, Croucher Peter, Samuelsz Errin, Vibat Cecile Rose, Guerrero Shiloh, Geis Jennifer, Berz David, Mann Elaina, Matheny Shannon, Rolfe Lindsey, Raponi Mitch, Erlander Mark G, Gadgeel Shirish

Abstract excerpt

INTRODUCTION: In approximately 60% of patients with NSCLC who are receiving EGFR tyrosine kinase inhibitors, resistance develops through the acquisition of EGFR T790M mutation. We aimed to demonstrate that a highly sensitive and quantitative next-generation sequencing analysis of EGFR mutations from urine and plasma specimens is feasible. METHODS: Short footprint mutation enrichment next-generation sequencing...

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PMID: 27468937
DOI: 10.1016/j.jtho.2016.05.035

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