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Targeting the histone demethylase LSD1 prevents cardiomyopathy in a mouse model of laminopathy

4 Jan 2021

Abstract excerpt

LMNA mutations in patients are responsible for a dilated cardiomyopathy. Molecular mechanisms underlying the origin and development of the pathology are unknown. Herein, using mouse pluripotent embryonic stem cells (ESCs) and a mouse model both harboring the p.H222P Lmna mutation, we found early defects in cardiac differentiation of mutated ESCs and dilatation of mutated embryonic hearts at E13.5, pointing to a...

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PMID: 33393499
DOI: 10.1172/jci136488

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