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Article

Altered striatum centered brain structures in SHANK3 deficient Chinese children with genotype and phenotype profiling.

Progress in neurobiology - 1 May 2021

Liu Chunxue, Li Dongyun, Yang Haowei, Li Huiping, Xu Qiong, Zhou Bingrui, Hu Chunchun, Li Chunyang, Wang Yi, Qiao Zhongwei, Jiang Yong-Hui, Xu Xiu

Abstract excerpt

SHANK3 deficiency represents one of the most replicated monogenic risk factors for autism spectrum disorder (ASD) and SHANK3 caused ASD presents a unique opportunity to understand the underlying neuropathological mechanisms of ASD. In this study, genetic tests, comprehensive clinical and neurobehavioral evaluations, as well as multimodal structural MRI using voxel-based morphometry (VBM) and tract-based spatial...

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Identifiers

PMID: 33388374
DOI: 10.1016/j.pneurobio.2020.101985
PMCID: PMC8572121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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