Article
NAT8 Variants, N-Acetylated Amino Acids, and Progression of CKD.
Clinical journal of the American Society of Nephrology : CJASN - 31 Dec 2020
Luo Shengyuan, Surapaneni Aditya, Zheng Zihe, Rhee Eugene P, Coresh Josef, Hung Adriana M, Nadkarni Girish N, Yu Bing, Boerwinkle Eric, Tin Adrienne, Arking Dan E, Steinbrenner Inga, Schlosser Pascal, Köttgen Anna, Grams Morgan E
Abstract excerpt
BACKGROUND AND OBJECTIVES: Genetic variants in NAT8, a liver- and kidney-specific acetyltransferase encoding gene, have been associated with eGFR and CKD in European populations. Higher circulating levels of two NAT8-associated metabolites, N-δ-acetylornithine and N-acetyl-1-methylhistidine, have been linked to lower eGFR and higher risk of incident CKD in the Black population. We aimed to expand upon prior...
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