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Article

Kidney-disease-associated variants of Apolipoprotein L1 show gain of function in cation channel activity.

The Journal of biological chemistry - 1 Jan 2000

Bruno Jonathan, Edwards John C

Abstract excerpt

Variants in Apolipoprotein L1 (ApoL1) are known to be responsible for increased risk of some progressive kidney diseases among people of African ancestry. ApoL1 is an amphitropic protein that can insert into phospholipid membranes and confer anion- or cation-selective permeability to phospholipid membranes depending on pH. Whether these activities differ among the variants or whether they contribute to disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33380423
DOI: 10.1074/jbc.RA120.013943
PMCID: PMC7948812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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