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Article

Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins.

PloS one - 1 Jan 2012

Mades Andreas, Gotthardt Katherina, Awe Karin, Stieler Jens, Döring Tatjana, Füser Sabine, Prange Reinhild

Abstract excerpt

The Sec61 translocon of the endoplasmic reticulum (ER) membrane forms an aqueous pore, allowing polypeptides to be transferred across or integrated into membranes. Protein translocation into the ER can occur co- and posttranslationally. In yeast, posttranslational translocation involves the heptameric translocase complex including its Sec62p and Sec63p subunits. The mammalian ER membrane contains orthologs of...

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Identifiers

PMID: 23166619
DOI: 10.1371/journal.pone.0049243
PMCID: PMC3499540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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