Article
Computational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample.
Molecular psychiatry - 1 Jun 2026
Luther Lauren, Cooper Jessica A, Treadway Michael T, Knippenberg Anna R, Walker Elaine F, Gold James M, Waltz James A, Schiffman Jason, Ellman Lauren M, Mittal Vijay A, Zinbarg Richard E, Silverstein Steve M, Corlett Philip R, Powers Albert R, Woods Scott W, Allen Daniel N, Lahti Adrienne C, Strauss Gregory P
Abstract excerpt
Effort-based decision-making (EBDM) impairments predict negative symptoms across multiple psychiatric diagnoses. However, it is unclear whether equifinality is present and different disorders reach the same clinical endpoint of negative symptoms via different mechanistic EBDM processes. This study used computational modeling to isolate processes underlying EBDM in a large severe mental illness-spectrum sample....
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