Computational phenotyping of effort-based decision-making in type-2 diabetes on and off semaglutide.

doi:10.1038/s41386-026-02433-y

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Article

Computational phenotyping of effort-based decision-making in type-2 diabetes on and off semaglutide.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2026

Mehrhof Sara Z, Fleming Hugo, Nord Camilla L

Abstract excerpt

Motivation plays a fundamental role in human behaviour. Dopaminergic pathways have long been implicated in individual differences in motivation. Emerging evidence suggests such neural mechanisms interact with metabolic processes to coordinate energy expenditure with energy resources, thereby linking motivation with metabolic health. We ask whether a cognitive-computational index of motivation-reliably linked to...

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Topics

Humans
Semaglutide
Diabetes Mellitus, Type 2
Female
Decision Making
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Motivation

Glucagon-Like Peptides

Middle Aged

Hypoglycemic Agents

Phenotype

Aged

Reward

Source

Open in PubMed Open full text

Identifiers

PMID: 42086986
DOI: 10.1038/s41386-026-02433-y
PMCID: PMC13597482

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