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Effort Aversion and Reward Sensitivity in Schizophrenia: Computational Phenotyping of Motivational Deficits across Behavioral Tasks.

Schizophrenia bulletin - 7 Mar 2026

Pigeon Etienne, Smadja Sarah, Berkovitch Lucie, Dhôte Jacob, Jaffré Claire, Gauthier Claire, Abdel-Ahad Pierre, Le Bouc Raphaël, Daunizeau Jean, Gaillard Raphaël, Pessiglione Mathias, Vinckier Fabien

Abstract excerpt

BACKGROUND: Motivational deficits have a major impact on the quality of life of patients with schizophrenia (SCZ) and respond poorly to antipsychotic medication. However, the underlying mechanisms, which cannot be accessed through conventional questionnaire-based scoring, remain largely unknown. This study aims to identify dysfunctional mechanisms that generate motivation deficits in patients with SCZ. STUDY...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41863387
DOI: 10.1093/schbul/sbaf252
PMCID: PMC13005102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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