Article
Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2021
Ostkamp Patrick, Salmen Anke, Pignolet Béatrice, Görlich Dennis, Andlauer Till F M, Schulte-Mecklenbeck Andreas, Gonzalez-Escamilla Gabriel, Bucciarelli Florence, Gennero Isabelle, Breuer Johanna, Antony Gisela, Schneider-Hohendorf Tilman, Mykicki Nadine, Bayas Antonios, Then Bergh Florian, Bittner Stefan, Hartung Hans-Peter, Friese Manuel A, Linker Ralf A, Luessi Felix, Lehmann-Horn Klaus, Mühlau Mark, Paul Friedemann, Stangel Martin, Tackenberg Björn, Tumani Hayrettin, Warnke Clemens, Weber Frank, Wildemann Brigitte, Zettl Uwe K, Ziemann Ulf, Müller-Myhsok Bertram, Kümpfel Tania, Klotz Luisa, Meuth Sven G, Zipp Frauke, Hemmer Bernhard, Hohlfeld Reinhard, Brassat David, Gold Ralf, Gross Catharina C, Lukas Carsten, Groppa Sergiu, Loser Karin, Wiendl Heinz, Schwab Nicholas
Abstract excerpt
Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (nNationMS = 946, nBIONAT = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated...
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